| Thu, 9/8/22 to Wed, 9/14/22Week 1 |
| Thursday, September 8, 2022 |
| 7:25 pm | Buffalo Bills | | vs. | Los Angeles Rams | | SoFi Stadium |
| Sunday, September 11, 2022 |
| 12:00 pm | Cleveland Browns | | vs. | Carolina Panthers | | Bank of America Stadium |
| 12:00 pm | Jacksonville Jaguars | | vs. | Washington Commanders | | FedEx Field |
| 3:25 pm | Kansas City Chiefs | | vs. | Arizona Cardinals | | State FarmStadium |
| 4:25 pm | New York Giants | | vs. | Tennesse Titans | | Nissan Stadium |
| National League |
| 12:00 pm | Philadelphia Eagles | | vs. | Detroit Lions | | Ford Field |
| 12:00 pm | San Francisco 49ers | | vs. | Chicago Bears | | Soldier Field |
| 7:20 pm | Tampa Bay Buccaneers | | vs. | Dallas Cowboys | | AT&T Stadium |
| NFC North |
| 3:25 pm | Green Bay Packers | | vs. | Minnesota Vikings | | U.S. Bank Stadium |
| NFC South |
| 12:00 pm | New Orleans Saints | | vs. | Atlanta Falcons | | Mercedes-Benz Stadium |
| American League |
| 12:00 pm | Baltimore Ravens | | vs. | New York Jets | | MetLife Stadium |
| AFC East |
| 12:00 pm | New England Patriots | | vs. | Miami Dolphins | | Hard Rock Stadium |
| AFC North |
| 12:00 pm | Pittsburgh Steelers | | vs. | Cincinnati Bengals | | Paycor Stadium |
| AFC South |
| 12:00 pm | Indianapolis Colts | | vs. | Houston Texans | | NRG Stadium |
| AFC West |
| 3:25 pm | Las Vegas Raiders | | vs. | Los Angeles Chargers | | SoFi Stadium |
| Monday, September 12, 2022 |
| 7:20 pm | Denver Broncos | | vs. | Seattle Seahawks | | Lumen Field |
| Thu, 9/15/22 to Wed, 9/21/22Week 2 |
| Thursday, September 15, 2022 |
| American League |
| AFC West |
| 7:15 pm | Los Angeles Chargers | | vs. | Kansas City Chiefs | | GEHA Field at Arrowhead Stadium |
| Sunday, September 18, 2022 |
| National League |
| 12:00 pm | Carolina Panthers | | vs. | New York Giants | | MetLife Stadium |
| 12:55 pm | Washington Commanders | | vs. | Detroit Lions | | Ford Field |
| NFC North |
| 7:20 pm | Chicago Bears | | vs. | Green Bay Packers | | Lambeau Field |
| NFC South |
| 12:00 pm | Tampa Bay Buccaneers | | vs. | New Orleans Saints | | Caesars Superdom |
| American League |
| 12:00 pm | New York Jets | | vs. | Cleveland Browns | | FirstEnergy Stadium |
| Thu, 9/22/22 to Wed, 9/28/22Week 3 |
| Sunday, September 25, 2022 |
| 12:00 pm | Houston Texans | | vs. | Chicago Bears | | Soldier Field |
| Thu, 9/29/22 to Wed, 10/5/22Week 4 |
| Sunday, October 2, 2022 |
| National League |
| 12:00 pm | Chicago Bears | | vs. | New York Giants | | MetLife Stadium |
| Thu, 10/6/22 to Wed, 10/12/22Week 5 |
| Sunday, October 9, 2022 |
| National League |
| NFC North |
| 12:00 pm | Chicago Bears | | vs. | Minnesota Vikings | | U.S. Bank Stadium |
| Thu, 10/13/22 to Wed, 10/19/22Week 6 |
| Thursday, October 13, 2022 |
| National League |
| 7:15 pm | Washington Commanders | | vs. | Chicago Bears | | Soldier Field |
| Thu, 10/20/22 to Wed, 10/26/22Week 7 |
| Monday, October 24, 2022 |
| 7:15 pm | Chicago Bears | | vs. | New England Patriots | | Gillette Stadium |
| Thu, 10/27/22 to Wed, 11/2/22Week 8 |
| Sunday, October 30, 2022 |
| National League |
| 12:00 pm | Chicago Bears | | vs. | Dallas Cowboys | | AT&T Stadium |
| Thu, 11/3/22 to Tue, 11/8/22Week 9 |
| Sunday, November 6, 2022 |
| 12:00 pm | Miami Dolphins | | vs. | Chicago Bears | | Soldier Field |
| Thu, 11/10/22 to Wed, 11/16/22Week 10 |
| Sunday, November 13, 2022 |
| National League |
| NFC North |
| 12:00 pm | Detroit Lions | | vs. | Chicago Bears | | Soldier Field |
| Thu, 11/17/22 to Wed, 11/23/22Week 11 |
| Sunday, November 20, 2022 |
| National League |
| 12:00 pm | Chicago Bears | | vs. | Atlanta Falcons | | Mercedes-Benz Stadium |
| Thu, 11/24/22 to Wed, 11/30/22Week 12 |
| Sunday, November 27, 2022 |
| 12:00 pm | Chicago Bears | | vs. | New York Jets | | MetLife Stadium |
| Thu, 12/1/22 to Wed, 12/7/22Week 13 |
| Sunday, December 4, 2022 |
| National League |
| NFC North |
| 12:00 pm | Green Bay Packers | | vs. | Chicago Bears | | Soldier Field |
| Thu, 12/15/22 to Wed, 12/21/22Week 14 |
| Sunday, December 18, 2022 |
| National League |
| 12:00 pm | Philadelphia Eagles | | vs. | Chicago Bears | | Soldier Field |